Folate contributes to: maternal tissue growth during pregnancy, plays a role in the process of cell division, contributes to the reduction of tiredness and fatigue; normal blood formation; normal amino acid synthesis; normal homocysteine metabolism and normal psychological function.
Additional Warnings: 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.