Rosemary Supreme™ was developed as a collaboration between Dr. Walter Schmitt and Dr. Michael Lebowitz. Our source is organically grown, and has gone through extensive clinical testing to find the highest quality and most therapeutically effective source on the market. Rosemary has three main therapeutic properties. 1, it is a powerful antioxidant with immune modulating properties [1, 2]. 2, it possesses extrahepatic estrogen breakdown effects [3]. 3, it may enhance cognitive ability [4]. In addition to modulation of estrogen breakdown, Rosemary also can inhibit the binding of dihydrotestosterone to androgen receptors, which can cause an increase in hair regrowth [5]. Rosemary contains three antioxidant substances that have potentially beneficial properties for our health: rosmarinic acid, carnosic acid, and ursolic acid [6]. Rosmarinic acidRosmarinic acid impacts estrogen breakdown in a positive way. Estradiol and estrone are detoxified via pathways that can be protective or carcinogenic, especially to tissues such as the breast and prostate. Rosmarinic acid has been shown to direct the metabolism of these estrogens toward the protective 2-hydroxy estrone pathway and away from the carcinogenic 4-hydroxy estrone and 16-hydroxy estrone pathways [3]. Rosmarinic acid also has important antioxidant effects. In the arachidonic acid cascade it shifts the production of the highly inflammatory leukotriene B4 toward the production of prostaglandin E2 [7, 8]. It also inhibits the complement system, the inflammatory activity driven by the innate immune system [9]. In mice, it has been shown to inhibit the allergic airway inflammation induced by house dust mites in vivo [10]. Carnosic acidCarnosic acid, and its metabolite carnosol also have antioxidant properties including neuroprotective effects in the brain. These effects include increasing reduced glutathione and protecting against middle cerebral artery ischemia/reperfusion [11]. Carnosol has been shown to inhibit lipopolysaccharide (LPS) and interferon-ã (IFNã) induced nitrite production by mouse peritoneal cells by more than 50%. Nitric oxide and the further production of peroxynitrate and nitrite have DNA damaging and carcinogenic effects [12]. Carnosol performs this antioxidant activity by decreasing nitric oxide production via inhibition of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-êB) promoter activity. These activities provide possible mechanisms for its anti-inflammatory and chemopreventive action [13]. Ursolic AcidUrsolic acid has been found to reduce muscle atrophy, stimulate muscle growth, increase brown fat, and decrease diet-infuced obesity in mice [14]. Ursolic acid has potential use as a cardioprotective compound [15]. Anti-microbial activity:Rosemary has been shown to possess antimicrobial properties also. In one study it inhibited the adherence ability and biofilm development of the C. albicans and C. tropicalis [16]. Another study showed its antibiofilm activity more effective than chlorhexidine against Streptococcus mutans and Streptococcus pyogenes biofilms [17]. It has also been shown to inhibit biofilm formation of MRSA [18]. Anti-cancer activity:Rosemary has shown to possess anti-cancer properties against prostate, breast, skin, leukemia, and colon cancer. It also uniquely has selective toxicity towards cancer cells versus non-tumorigenic cells [19, 20]. In one study of Rosemary and breast cancer cells they found that it not only exerts antitumor activity against breast cancer cells, but also possesses antitumor effects against estrogen-dependent breast cancer subtypes, and significantly enhanced the effect of breast cancer chemotherapy [21]. Summation:So to sum up - Rosemary should be thought of as a product to help estrogen degradation, as a powerful antioxidant, and as a cardioprotective and neuroprotective agent as well as in many autoimmune disorders. We recommend considering using Rosemary Supreme in any free radical / inflammatory disease (including autoimmunity), in patients with hormonal imbalances (specifically estrogen), and chemical sensitivities. Any female or male patient with personal or family history of estrogen driven cancers should be evaluated for supplementation with Rosemary. References available on request.
